Plague Research Today is a free monthly online journal that collates and summarizes the latest research about Plague, including details on bubonic plague, yersinia pestis, infection, types, treatment.

Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague.

Williamson ED, Stagg AJ, Eley SM, Taylor R, Green M, Jones SM, Titball RW

Dstl Porton Down, Salisbury, Wilts SP4 0JQ, UK. dewilliamson@dstl.gov.uk

Protection against aerosol challenge with > 300 MLD of Yersinia pestis was observed 7 days after a single immunisation of mice with the F1+V vaccine. At day 60, mice were protected against injected challenge (10(7)MLD) in a vaccine dose-related manner. Recall responses to rV in splenocytes ex vivo at day 98 correlated significantly (p<0.001) with the immunising dose-level of V antigen; no memory response or anti-V serum IgG was detected in killed whole cell vaccine (KWCV) recipients. This may explain the susceptibility of KWCV recipients to aerosol challenge and the enhanced protection conferred by the F1+V sub-unit vaccine, particularly since the anti-F1 responses induced by either vaccine were similarly IgG1-polarised.

Published 25 December 2006 in Vaccine, 25(6): 1142-8.
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